Description: MEIS inhibitor-2
Synonyms: MEISi-2, small molecule inhibitor-2 of MEIS proteins, small molecule inhibitor of MEIS homeodomain, small molecule inhibitor of MEIS1, small molecule inhibitor of MEIS2, small molecule inhibitor of MEIS3,
Chemical Formula: C18H14N2O3
Purity: ≥95% (HPLC)
MEIS proteins have been implicated in various cellular processes including regeneration, stem cell/progenitor function, cellular metabolism, cell proliferation, redox state, apoptosis, RLS and tumorigenesis. Small molecule MEISi inhibits transcriptional activity of MEIS proteins by targeting the homeodomain of MEIS proteins.
We have used our proprietary tools and expertise in MEIS biology to develop MEIS inhibitors. We have performed in silico, in vitro, ex vivo and in vivo assays to validate small molecule MEIS inhibitors. Newly developed small molecule MEIS inhibitors are cell-permeant, and dose dependent. They could be used to target MEIS related pathways.
MEISi-2 or MEISi-EX may block cancer growth in vitro. MEISi-2 can downregulate expression of MEIS1 target genes including Hypoxia inducible factor (HIF)-1α and HIF-2α, and associated glycolysis genes HK2, Eno1, Glut1, and LDHA. Apoptosis can be induced with MEISi-2 treatments.
Novel MEIS inhibitors are now available in 5, 10 and 25 mg vials to ship internationally. For your inquiries and orders please email to email@example.com.
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